Shree. Sureshadada Jain Institutes of Pharmaceutical Education and Research, Jammer, Maharashtra (India)
A quinolone antibiotic is a member of a large group of broad-spectrum bactericides that share a bicyclic core structure related to the compound 4-quinolone. They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry. Nearly all quinolone antibiotics in modern use are fluoroquinolones, which contain a fluorine atom in their chemical structure and are effective against both gram-negative and grampositive bacteria. The affinity of quinolones for the gamma-aminobutyric acid (GABA) receptor may induce CNS adverse effects; these effects are enhanced by some nonsteroidal anti-inflammatory drugs (NSAIDs). This article gives special emphasis on comparison between two fluoroquinolones such as Gatifloxacin and Sparfloxacin which will be useful for the readers to select the drug for therapy
Gatifloxacin, Sparfloxacin, Fluoroquinolones, comparison
