(18.97.9.175)
[ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2014, Volume : 7, Issue : 9
First page : ( 1038) Last page : ( 1040)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Development and Validation of UV-Spectroscopic method for the Estimation of Bicalutamide in Pure and Pharmaceutical Dosage Form

Manala Sowmya1,*, Samala Alivelu2, Sasikala M.2, Chatlapelli Kishore3

1Department of Pharmaceutical Analysis, Priyadarshini College of Pharmaceutical Sciences, Chowdaryguda (V), Ghatkesar (M), Hyderabad, AP

2Department of Pharmaceutical Chemistry, Holy Mary Institute of Pharmacy, Bogaram (V), Keesara (M). Hyderabad, AP

3Department of Pharmaceutics, Holy Mary Institute of Pharmacy, Bogaram (V), Keesara (M), Hyderabad, AP

*Corresponding Author E-mail: manalasowmya@gmail.com

Online published on 22 October, 2014.

Abstract

The present research work discusses the development of a UV estimation method for Bicalutamide. A simple, accurate, rapid, sensitive and precise UV spectrophotometric method has been developed for the estimation of Bicalutamide in pure and pharmaceutical dosage forms. Beer's law was obeyed in the range of 2.5–15 μg/ml at 272nm and shows a correlation coefficient of 0.999. The concentrations of this drug were evaluated in laboratory mixture and marketed formulation. Accuracy was determined by recovery studies from tablet dosage form and ranges from 99.6 to 100.2%. Precision of present method was find out as repeatability, day to day and shows the values within acceptable limit (R.S.D ≤ 2 percentage).

Top

Keywords

Bicalutamide, UV spectrophotometer, Validation, Beer's law.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
862,258,949 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.