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Research Journal of Pharmacy and Technology
Year : 2014, Volume : 7, Issue : 9
First page : ( 1025) Last page : ( 1028)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Synthesis and Anti-Microbial Activity of Some Novel Mannich Base Aryl Imidazole Derivatives

Girija K.1,*, Karthika S.1, Mathew Nisha2

1Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-605 006

2Vector Control Research Center [ICMR], Indira Nagar Complex, Gorimedu, Puducherry-605 006

*Corresponding Author E-mail: girijanarasimhan66@gmail.com

Online published on 22 October, 2014.

Abstract

Mannich base aryl imidazole derivatives were synthesized by condensing Primary aromatic amines and Aryl aldehydes in presence of glacial acetic acid to give respective Schiffs bases, which on further treatment with Ammonium acetate and Isatin in presence of glacial acetic acid to produce aryl imidazoles followed by stirring with formaldehyde and primary amines for 1 hour in presence of ethanol to yield the corresponding Mannich bases. The purity of the synthesized compounds were checked by TLC and characterized by FT-IR, Mass spectroscopy. All the synthesized compounds were evaluated for the Anti-bacterial and Anti-fungal activity. The compounds 1a, 1b, 1c, 1e, 2a showed good antibacterial activity against Staphylococcus aureus and E.coli compared to standard Ciprofloxacin. The compounds 1a, 1c, 2a showed good antifungal activity against Candida albican compared to standard Amphotericin B.

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Keywords

Aryl Imidazoles, Mannich Base, Primary Amines, Formaldehydes, Antibacterial And Antifungal, Ciprofloxacin, Amphotericin B.

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