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Research Journal of Pharmacy and Technology
Year : 2014, Volume : 7, Issue : 9
First page : ( 995) Last page : ( 998)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Synthesis and Biological Evaluation of Some Novel Pyrimidine Derivatives Derived from Chalcones

Bhat K. Ishwar, Kumar Abhishek*, Kumar Pankaj, Riyaz E.K.

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 22 October, 2014.

Abstract

A series of novel 6-(substituted phenyl)-4-(nitrophenyl) pyrimidin-2-ol (RPY1-RPY8) have been synthesized upon refluxing with 3-(4-nitrophenyl)-1-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 3-(4-nitrophenyl)-1-phenyl substituted prop-2-en-1-one (RC1-RC8) were prepared by reaction with 4nitrobenzaldehyde and substituted acetophenones in presence of NaOH. The structures of the final synthesized compounds were confirmed by IR, 1H NMR and mass spectra.

All the new compounds were screened for their in-vitro antimicrobial, antitubercular and cytotoxic activities. Most of the compounds have exhibited promising antibacterial, antifungal, antitubercular and cytotoxic activities.

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Keywords

Chalcones, pyrimidines, antibacterial activity, antifungal activity, antitubercular activity, cytotoxic activity.

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