Formulation and In vitro Evaluation of Gastroretentive Floating Tablets of Ivabradine Hydrochloride using Different Polymers. Senthil S.P.1, Sreeja M.K.1, Vincent Jerin2, Singh Manoj Kumar2 1Dept. of Pharmaceutics, Erode College of Pharmacy and Research, Erode, Tamil Nadu 2Bafna Pharmaceuticals Ltd., Chennai *Corresponding Author E-mail:
Online published on 22 October, 2014. Abstract The study was aimed on preparing gastro retentive floating tablets with Ivabradine HCl using different polymers such as HPMC K 100 and Xanthan gum. Sodium bicarbonate and citric acid were used as gas generating agents. Tablets was prepared by direct compression methodand subjected to various evaluation parameters like hardness, thickness, friability, weight variation, drug content uniformity, floating lag time, floating duration time, invitro release studies. Release kinetics was explained with zero order, first order, Higuchi and Peppas kinetics. The optimized formulation was F8 and it showed an invitro drug release of 99.84% at the end of 8th hour, following Peppas kinetics for the release. Top Keywords Ivabradine HCl, HPMC K100, Xanthan gum, Floating tablets. Top |