Evaluation of Antioxidant and Cytotoxic Potential of Different Extracts from the Leaves of Aegle marmelos L. Urmi Kaniz Fatima1, Md. Chowdhury Ashraf Uddin2, Diba Farhana3, Rahman Khandaker Ashfaqur1, Md. Habib Razibul3, Hamid Kaiser3,* 1Department of Pharmacy, Jahangirnagar University, Bangladesh 2International Islamic University, Chittagong, Bangladesh 3Department of Pharmacy, East West University, Bangladesh *Corresponding Author E-mail: kaiserpharm_1134@yahoo.com
Online published on 31 October, 2013. Abstract The present study was carried out to assess the cytotoxic and antioxidant activities of methanol, ethyl acetate and nhexane extract of leaves of Aegle marmelos or Bael. The cytotoxicity assay was carried out by brine shrimp lethality bioassay. The antioxidant properties were assessed by using 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH) and nitric oxide (NO) scavenging capacity. The methanol, ethyl acetate and n-hexane extracts showed potential antioxidant activity with IC50 values of 6.629, 4.383 and 3.606 μg/ml respectively and comparison was made with standard ascorbic acid having IC50 value of 2.687μg/ml. The methanol extract depicted potential antioxidant activity with IC50 value of 1.233μg/ml in nitric oxide scavenging capacity assay compared to standard ascorbic acid of 3.712μg/ml. The extracts showed potent cytotoxic activity with LC50 values of 4.482, 5.278 and 5.278 μg/ml respectively whereas the standard vincristine sulfate showed 3.364μg/ml. The three extracts of leaves of A. marmelos possessed significant antioxidant and cytotoxic potentials in this experiment. Top Keywords Aegle marmelos, cytotoxicity, antioxidant, brine shrimp, DPPH. Top |