Metronidazole Encapsulation within Chitosan Coated Eudragit RL Microsphers for Site Specific Delivery Sivakumar R.1,*, Ganesan V.1, Viyas Markand2, Rajendran N.N.2, Kommala M.3 1The Erode College of Pharmacy, Erode – 638112 (TN) 2Swamy Vivekanandha College of Pharmacy, Tiruchengode -637 205, India 3Mohamed Sathak A.J. College of Pharmacy, Chennai-600 119 *Corresponding Author E-mail: rrsk1879@gmail.com
Online published on 3 April, 2013. Abstract The purpose of the work was to formulate and evaluate mucoadhesive microspheres containing metronidazole for the potential delivery of the drug to the colon. Microspheres were prepared by emulsion solvent evaporation method and filled into capsules for polymeric coating. These preparations were characterized for micromeritics study, morphology, percentage drug content, encapsulation efficiency, Percent mucoadhesion and in vitro drug release study. All the microspheres were spherical in shape smooth surface with a mean diameter 58.9 μm – 205.1 μm. The release mechanism were anomalous (non-fickian) diffusion mechanism. The prolonged colonic residence time and enhanced metronidazole stability resulting from the mucoadhesion microspheres of metronidazole might make contribution of complete eradication of amoebiasis. Top Keywords Metronidazole, Colon targeting, Mucoadhesive microspheres, Eudragit RL, Chitosan. Top |