Design, Synthesis and Biological Evaluation of Methyl-2-(2-(Arylideneamino) Oxazol-4-Ylamino) Benzoxazole-5-Carboxylate Derivatives as New Antiinflammatory Agents Chilumula Nageshwar Rao1, Ampati Srinivas2, Gudipati Rajyalaxmi2, Manda Sarangapani2, Gaday Dayakar1,* 1Departmet of Chemistry, Kakatiya University, Warangal, A.P-India, 506009 2University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A.P.-India, 506009 *Corresponding Author E-mail: profgdayakar@gmail.com
Online published on 3 April, 2013. Abstract A series of novel methyl-2-(arylideneamino)oxazol-4ylamino)benzoxazole-5-carboxylate derivatives synthesized. The structures of these compounds were established by IR, 1H NMR, 13C NMR, Mass spectral data and elemental analysis. Compounds were evaluated for their anti-inflammatory activity. Derivatives VIId and VIIe exhibited very good and almost equal anti-inflammatory activity in carrageenan-induced rat paw edema method compared with the standard drug Diclofenac Sodium. Top Keywords Benzoxazole derivatives, IR, 1H NMR and Mass spectroscopy, methyl-2-(arylideneamino)oxazol-4ylamino) benzoxazole -5-carboxylate, anti inflammatory. Top |