Antidiarrheal, Analgesic and Antioxidant Activities of Trapa bispinosa Roxb. Fruits Karmakar U.K.*, Rahman K.S., Biswas N.N., Islam M.A., Ahmed M.I., Shill M.C., Paul P., Kamruzzaman M. Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh *Corresponding Author E-mail: ukk146@gmail.com
Online published on 3 April, 2013. Abstract The ethanolic extract of fruits of Trapa bispinosa Roxb (Family: Trapaceae) was screened for its antidiarrheal, analgesic and antioxidant activities. The fruit extract showed a significant (P<0.01) antidiarrheal activity against castor oil induce diarrhea in mice in which it decreased the frequency of defecation and increased the mean latent period at the dose of 500 mg/kg body weight. In acetic acid induced writhing test the extract, at the dose of 500 mg/kg, exhibited a maximum of 50.17% inhibition (P<0.01) of writhing reflex compared to the reference drug diclofenac sodium 55.22% (P<0.01). The antioxidant property of the extract was assessed by 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay. The extract showed antioxidant activity (IC50 about 08 μg/ml) which was comparable to standard drug ascorbic acid (IC50 about 10 μg/ml). The results tend to suggest that the extract might possess some chemical constituents that are responsible for antidiarrheal, analgesic and antioxidant activities. Top Keywords Trapa bispinosa Roxb, antidiarrheal activities, analgesic activities, antioxidant activities. Top |