Synthesis, Spectral Characterization and Pharmacological Screening of 1Methylene-4-(5-(4-(Phenylamino)Phenyl)-1,3,4-Thiadiazol-2-Yl) Thiosemicarbazide Derivatives. Singh Anoop1,*, Rana A.C.2 1Dept. of Pharmaceutical Chemistry, Bhupal Noble's College of Pharmacy, Udaipur (Rajasthan) India-313001 2Rayat Institute of Pharmacy, Rail Majra, Ropar (Punjab) India *Corresponding Author E-mail: anoop_medchem@yahoo.co.in
Online published on 3 April, 2013. Abstract Recently a series of 1-methylene-4-(5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-yl) thiosemicarbazide derivatives were synthesized and their pharmacologically evaluated for antimicrobial activities. The purpose of this study was to evaluate the potency of the title compounds on bacterial and fungal activities by varying the substituted in the 1-methylene-4-(5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-yl)thiosemicarbazide derivatives. All compounds of this series showed promising antimicrobial activities. It was found that some of these compounds possess marked antifungal and antibacterial properties comparable in efficiency to the reference drug Flukanazole and Ciprofloxacin respectively. In present study the structures of compounds were confirmed by UV, IR, 1H NMR. Top Keywords 1-methylene-4-(5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-yl) thiosemicarbazide derivatives, antibacterial agents, antifungal agents, S. aureus, B. subtilis, E. coli, K. pneumoniae, C. albican, A. niger and UV, IR, 1H NMR spectroscopy. Top |