Synthesis and Cytotoxic Studies of Newer 3-(1-Benzofuran-2-Yl)-5(Substituted Aryl) Isoxazole Bhalgat Chetan M.1,*, Patil Sachin L.2, Chitale Sandeep K.1, Randive Krantisinha1, Patil Kumar G.1, Patil Santosh1 1Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G.Nagara-571448, Mandya 2Principal, Mayani College of Pharmacy, Mayani-415102, Tal: Khatav, Dist: Satara *Corresponding Author E-mail: chetanbhalgat2004@yahoo.co.in
Online published on 3 April, 2013. Abstract The 3-(1-benzofuran-2-yl)-5-(substituted phenyl) isoxazole have been synthesized by the reaction of Benzofuran chalcone with hydroxylamine hydrochloride in presence of sodium acetate in ethanol. All the compounds were synthesized by conventional method and characterized by IR, 1H NMR and mass spectral data. The new synthesized derivatives I1-I7 was evaluated for in vitro cytotoxic activity on HeLa cell lines. Compounds I1-I7 was scheduled for evaluation against full panel of human cervical cancer cell lines at the minimum seven concentrations at two fold dilutions. Top Keywords Benzofuran, isoxazole, chalcone, conventional, cytotoxic activity. Top |