Synthesis and Antihyperglycemic Activity of Novel 6,7,8,9 Tetra Hydro-5H-5-Phenyl-2-Benzylidine-3-Substituted Hydrazino Thiazolo (2, 3-B) Quinazoline Derivatives and Analogues Selvam Theivendren Panneer1,*, Kumar Palanirajan Vijayaraj2 1Department of Biotechnology, Acharya Nagarjuna University, Guntur -522 510, Andhrapradesh, India 2School of Pharmacy, UCSI University, Jalan Menara Gading, 56000 Cheras, Kuala Lumpur, Malaysia *Corresponding Author E-mail: tpsphc@gmail.com
Online published on 3 April, 2013. Abstract As series of heterocycles, 6,7,8,9 Tetra hydro-5H-5-phenyl-2-benzylidine-3-substituted hydrazino thiazolo (2, 3-b) quinazoline 6a-o derivatives were synthesized and tested for Antihyperglycemic activity. Their antihyperglycemic activity was evaluated by Streptozotocin (STZ) and Sucrose-loaded (SLM) model. All the newly synthesized compounds chemical structures were confirmed by IR, 1H-NMR, mass spectroscopy and elemental analyses. The results of studies indicate that the compounds 6a, b, d, j, o displayed significant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. Top Keywords Thiazolo quinazoline, Thiazolo quinazoline phenyl hydrazone, Aromatic aldehydes substitution, Benzylidine thiazolo quinazoline phenyl hydrazone, Antihyperglycemic activity. Top |