A Systematic Review on Floating Drug Delivery System Kumar S. Vijaya1,*, Deka Manoj Kumar1, Bagga Manish1, Kala M. Sasi1, Sharan Guru2 1Department of Pharmacology, Himalayan Pharmacy Institute, E. Sikkim -737136 2IIMT College of Medical Science, Meerut, U.P. *Corresponding Author E-mail: vijayvijay66@yahoo.co.in
Online published on 3 April, 2013. Abstract The objective of our review is to compile the recent advancements and literatures regarding the novel dosage form i.e. the floating drug delivery systems (FDDS) that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. The methodologies used in the development of FDDS by formulating effervescent and non effervescent floating tablets based on buoyancy mechanism. By utilizing above feasible approaches it is possible to deliver drugs which have narrow therapeutic window. Our review article suggests that gastro retentive dosage forms (GRDFs) can be the possible way to improve patient compliance and robustness. Various pharma companies adopted advance technologies to make FDDS commercialized in large scale despite of several limitations. So, in future we hope to have a rational GRDF that's promises to be a potential approach for gastric retention. Top Keywords Floating drug, Effervescent ad Non effervescent, In vitro evaluation. Top |