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Research Journal of Pharmacy and Technology
Year : 2023, Volume : 16, Issue : 4
First page : ( 1622) Last page : ( 1626)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2023.00265

Proficient protocol for synthesis of quinoline and pyrazole derivatives using greener reagent: Glycerol

Pahelkar Akshata R.*, Bhadke Priyanka K.**, Bhagat Saket B.***, Telvekar Vikas N.****

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai - 400019, (Maharashtra) India

*Corresponding Author E-mail: vikastelvekar@rediffmail.com

**akspahelkar@gmail.com

***bhadkepriyanka@gmail.com

****saketbhagat@gmail.com

Online Published on 13 October, 2023.

Abstract

A forthright, effectual and more viable catalyst-free method has been developed for the synthesis of quinolone and pyrazole ring system in glycerol to achieve yields that were equivalent to or better than, those in conventional media. It is notable that the reaction was exclusively carried out in glycerol-acetic acid system, representing methodology is highly valuable from both environmental and economic points of view.

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Keywords

Green chemistry, Glycerol, Quinoline, Pyrazole, Acetic acid.

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