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Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 1
First page : ( 494) Last page : ( 498)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00080

Pharmacokinetic and pharmacodynamic studies of omeprazole co-crystals dry suspension

Gaddam Madhuri1,*, Ravouru Nagaraju2

1Department of Pharmaceutics, Rao's College of Pharmacy, Nellore, Andhra Pradesh, India

2Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati- 517502, Andhra Pradesh, India

*Corresponding Author E-mail:

Online Published on 13 June, 2022.

Abstract

A novel omeprazole co-crystals instant dry suspension dosage was formulated by applying co-crystallization which is a particle engineering technique to enhance the physicochemical properties. As omeprazole has major critical draw backs in their solubility and stability (acidic pH degradation, thermal sensitivity, photosensitivity and highly hygroscopic nature) bioavailability of omeprazole was drastically reduced and purpose of administration of drug was not fulfilled. There by this formulation was invented to check maid these problems. In this present study in-vivo evaluation were performed. Pharmacokinetic parameters and pharmacodynamic parameters were determined and statistically analysed. The prepared formulation of omeprazole produced reliable satisfaction in solving the drawback problems of pure omeprazole by enhancing bioavailability. Statistical analysis was done by one way ANOVA test with P value less than 0.0001, Dunnet multiple comparison test was performed between the groups with P value < 0.01 which was considered to be significant.

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Keywords

Omeprazole co-crystals, Pharmacokinetic parameters, Pharmacodynamic studies and ulcer index.

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