The future prospective: Potential magnesium and calcium for detracting side effect cisplatin Alaydrus Syafika1,2,*, Diantini Ajeng1, Amalia Riezki1, Sriwidodo3, Chaerunisa Anis Yohana3, Wathoni Nasrul3 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java45363, Indonesia 2Department of Pharmacy, STIFA Pelita Mas Palu, Central Sulawesi, Indonesia 3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, West Java45363, Indonesia *Corresponding Author E-mail: syafikaalaydrus39@gmail.com
Online Published on 13 June, 2022. Abstract Cancer has been caused by more death globally and is associated with magnesium and calcium intake with some cancers. Some studies are shown as a protective agent against chemotherapy-induced nephrotoxicity and neurotoxicity. Despite magnesium and calcium are the opposite in inflammation, reabsorption regulation, and other physiological processes. However, it is important to maintain the balance between magnesium and calcium related to the micronutrients’ physiological functions. One of the cancer drugs can lead to hypomagnesemia and hypocalcemia electrolytes such as cisplatin. The purpose of this article is to review the cisplatin mechanism in electrolyte disorder and the association between potential magnesium and calcium for therapy of some cancer. Top Keywords Magnesium, Calcium, Cancer, Cisplatin. Top |