Protective effect of Colocasia esculenta on tnbs induced ulcerative colitis in mice Chandra Srikanta1, Roy Tathagata2,*, Bose Preeta3, Ghosh Somsubhra4, Paul Susanta5, Roychowdhury Victor6, Bose Anannya7, Acharya Ankita8 1Assistant Professor, Jakir Hossain Institute of Pharmacy, Miapur, Murshidabad,742225 2Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109 3Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109 4Assistant Professor, School or pharmacy, Techno India University, Salt Lake, Kolkata-700091, W.B 5Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109 6Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109 7Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109 8Assistant Professor, Department of Pharmaceutical Technology, JIS University, Kolkata-700109 *Corresponding Author E-mail: troy@jisuniversity.ac.in
Online Published on 13 June, 2022. Abstract Objective Ulcerative colitis (UC) is a recurrent ulceroinflammatory disease that is mainly restricted to colonic mucosa with variable colonic architecture distortion. Different types of drugs are used for management of UC namely Salfasalazine, Balsalazide, Mesalamine etc. However, they are associated with different types of adverse effects such as nausea, vomiting, skin rash, headache. Hence, we narrowed in on Colocasia esculenta and its available in India, Bangladesh, Pakistan. In our present study the anticolitic effects Colocasia esculenta in treatment the TNBS induced model for UC in mice were examined. Methods Male mice, 7 weeks of age, are selected. They are divided into various categories: Negative control groups treated with normal saline solution, positive control group treated with TNBS5%, standard group treated with Balsalazide 4mg/kg & TNBS 5%, Test(1) group treated with Colocasia esculenta 100mg/kg, Test(2) group treated with Colocasia esculenta 150 mg/kg, Test(3) group treated with Colocasia esculenta 250 mg/kg then we were performed various parameters such as DAI, Oxidative damage assessment, MPO Assessment. Results The results have been showed that Colocasia esculenta has significant activity against TNBS (5%) induced colitis when compared to the experimental control, with near normalization of colon architecture. Tissue oxidative stress was reduced with significant improvement in tissue levels of MDA &GSH. Furthermore, significant improvement in levels of myeloperoxidase (MPO) was observed. Conclusion It is concluded that Colocasia esculenta(250mg/kg) has got potent activity against TNBS (5%) induced ulcerative colitis (UC) due to its anti-inflammatory& antioxidant properties. Top Keywords Ulcerative colitis, Anti-inflammatory, Antioxidant, Colocasia esculenta, Myeloperoxidase. Top |