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Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 1
First page : ( 381) Last page : ( 384)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00062

Potency of Nigella sativa linn. seed as antidiabetic (preclinical study)

Sutrisna Em1,*, Azizah Tanti2, Wahyuni Sri1

1Medical faculty of Universitas MuhammadiyahSurakarta

2Pharmacy faculty of Universitas MuhammadiyahSurakarta

*Corresponding Author E-mail: es233@ums.ac.id

Online Published on 13 June, 2022.

Abstract

Background

Nigella sativa is reported to have an antioxidant effect, so allegedly has anti-diabetic effect. Objectives: The aim of this study is to explore ethyl acetate fraction of ethanol extract of Nigela sativa Linn. (EANS) effect toward blood glucose level in diabetic rats induced by alloxan.

Materials and Methods

Twenty five male rats (150–200 g). The rats were divided into five groups in which there were 5 rats in each group. Group I was treated by glibenclamide 0.63 mg/kg bw (positive control); Group II was treated by aqueous 2,5 ml/200 g bw (negative control); and Groups III; IV and V were treated by ethyl acetate of ethanol extract of N. sativa seed at a dosage of 250 mg/kg bw; 500 mg/kg bw and 1000mg/kg bw respectively.

Results

The results of this study are EANS can reduced blood glucose level on diabetic rats induced by alloxan. Nigella sativa has potencies anti-diabetic effect.

Conclusion

Nigella sativa Linn. seed has potency as anti-diabetic candidate.

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Keywords

Nigella sativa, Anti-diabetic, Ethyl acetate.

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