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Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 1
First page : ( 301) Last page : ( 304)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00049

High performance liquid chromatographic method for the determination of mesalamine in bulk drug and pharmaceutical dosage forms

Narala Srinivasa Rao1,*, Saraswathi K.2

1Department of Chemistry, R.V.R. & J.C. College of Engineering, Guntur, Andhra PradeshIndia

2Department of Chemistry, S.V. University, Tirupati, Andhra PradeshIndia

*Corresponding Author E-mail: srinunarala@gmail.com

Online Published on 13 June, 2022.

Abstract

A simple, rapid and sensitive reverse phase high performance liquid chromatographic method has been developed for the determination of Mesalamine in bulk drug and pharmaceutical dosage forms. It was carried out using a mobile phase of methanol and 0.025 M potassium dihydrogen phosphate buffer (65:35 v/v) on a kromosil C18 column (250 X 4.6 mm, 5µm) in an isocratic mode at a flow rate of 1.0 ml/min. with detection at 250 nm using a UV detector. The linearity was obtained in the concentration range of 20 -100 µg/ml. The developed method was found to be accurate for the determination of Mesalamine in tablet dosage forms.

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Keywords

Mesalamine, RP-HPLC, Method development, Validation, Recovery experiments.

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