(18.97.14.82)
[ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 1
First page : ( 236) Last page : ( 244)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00039

Synthesis of novel 6-(chloromethyl) - n2- (1 - (4-substituted phenyl) - 3-phenyl - 1h-pyrazol - 4-yl) methylene)-n4- aryl-1, 3, 5-triazine - 2, 4-diamine derivatives and their antimicrobial activity

Kushwaha Neelottama1,2,*, Sharma C.S.3

1Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, Uttar PradeshIndia

2Ph.D. Scholar, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan-313001, India

3Associate Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan-313001, India

*Corresponding Author E-mail: neelottama@gmail.com

Online Published on 13 June, 2022.

Abstract

A series of 6-(chloromethyl)-N2-(1-(4-substitutedphenyl)-3-phenyl-1H-pyrazol-4-yl) methylene)-N4-aryl-1, 3, 5-triazine - 2, 4-diamine 7(Aa-Gd) were synthesized using the appropriate synthetic procedure and characterized by spectral analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. The antibacterial activity was evaluated against Gram-positive strains (Staphylococcus aureus, Streptococcus aureus) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa) using benzyl penicillin and streptomycin as standard drugs. Further, these compounds were studied for antifungal activity against three strains of fungi (Candida albicans, Aspergillus fumigate and Aspergillus flavus) using Ketoconazole as a standard drug. In the presented study all the synthesized compounds showed significant antibacterial and antifungal activities.

Top

Keywords

Triazine, Pharmacophore, Antibacterial, Antifungal, Heterocyclic.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
861,138,265 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.