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Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 1
First page : ( 229) Last page : ( 235)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00038

Formulation and evaluation of lamotrigine loaded nanosponges

Satpathy Tarun Kumar1,*, Chaubey Neelesh1, Brahma Chandan Kumar2, Maheshwari Mittal3

1College of pharmacy, Sri Satya Sai University of Technology and Medical Sciences, SehoreMP, India

2Department of Pharmaceutical Technology, KJR College of Pharmacy, Rajahmundry, Andhra PradeshIndia

3A-One Pharmacy College, SNME Campus, Ahmedabad, Gujarat, India

*Corresponding Author E-mail: tarun.satpathy@gmail.com

Online Published on 13 June, 2022.

Abstract

The main purpose of this investigation study is to fabricate nanosponges with good entrapment efficiency and percentage of yield to enhance the solubility and dissolution rate of poorly water soluble antiepileptic molecules of Lamotrigine, which belongs to BCS - II class. Lamotrigine nanosponges were prepared using emulsion solvent diffusion technique and the immediate release tablets of lamotrigine nanosponges were prepared by direct compression method. Nanosponges were formulated using different polymers ratio like EC and PVA. The optimized batch containing ratio 2:1:2 of drug, ethyl cellulose and PVA shows maximum entrapment efficiency and percentage of yield. The optimized nanosponges of lamotrigine (F1) were subjected for Practical yield, drug content, Saturation solubility, zeta potential, Fourier transform Infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Scanning electron microscopy(SEM). The optimized formulations (F1) of nanosponge based immediate release tablets compression parameters were also studied. The In-vitro dissolution was carried out by USP apparatus type II (Paddle Method) with 900 ml of 0.1 N HCl at 50 rpm. At definite time intervals, 5 ml of the receptor fluid were withdrawn, filtered and analyzed spectro-photometrically at wave length 265 nm. The compressed lamotrigine nanosponge shows 99.7% at the end of dissolution and it follows first order kinetics and best fit with Higuchi's model. In this research solubility and dissolution demonstrated for nanosponge formulation.

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Keywords

Lamotrigine, Nanosponges, In- vitro dissolution rate, Kinetic release.

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