Tamarind seed polysaccharide mouth dissolving films for rapid drug release in the treatment of hypertension: In vitro evaluation Bhavanam Pamula Reddy1,*, Rahaman Shaik Abdul1, Varma M. Mohan2 1Department of Pharmaceutical Technology, Nirmala College of Pharmacy, Atmakuru, Andhra Pradesh - 522503, India 2Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh - 534202, India *Corresponding Author E-mail: pamula1114@gmail.com
Online published on 25 August, 2021. Abstract Tamarind seed polysaccharide (TSP) micro sized mouth dissolving films were prepared to release the Amlodipine besylate drug for hypertension. TSP mouth dissolving films were prepared by solvent evaporation method which was further examined under in vitro studies. In vitro antimicrobial activities for all the mouth dissolving films were conducted by diffusion method. Form the in vitro release profile, the AML-TSP was completely showed rapid release of drug up to 98.1% than the thin films of other formulations respectively in the period of time of 10 min. The prepared AML-TSP mouth dissolving films were evaluated for drug content, weight variation, thickness, pH, folding endurance, In vitro drug release and stability studies. AML8 showed the highest drug release at the 10 min time point. The AML8 mouth dissolving film with higher amount of superdisintegrant CCS and SSG showed fastest onset of drug release. Top Keywords TSP Mouth dissolving films, Hypertension, In vitro dissolution rate. Top |