Evaluation of anti-oxidant and anti-pyretic activity of fruits of Garcinia pedunculata Basak Mrinmoy*, Laskar Moksood Ahmed, Goswami Priyanka Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati - 26. Assam, India *Corresponding Author E-mail: mrinmoybsk@gmail.com
Online published on 25 August, 2021. Abstract Most of the synthetic drugs used at present as analgesic and anti-inflammatory agents cause many side effects and toxic effects. Many medicines of plant origin with analgesic and anti-inflammatory activity have been used since long time without adverse effects. The purpose of the study was to explore the anti-pyretic and anti-oxidant activity of fruits of Garcinia pedunculata. The fruit of G. pedunculata was collected from Shillong, Meghalaya and extraction is done by using methanol as a solvent. The methanol extract shows the presence of carbohydrate, glycoside, alkaloids, phenol and flavonoids. Acute anti-pyretic activity for the extract was investigated in pyrexia rat. Temperature level was determined after lhours, 4 hours, 8 hours and 12 hours after giving the extract dose of 100mg/kg and 200mg/kg body weight, and it was found to produce a significant reduce in fever. DPPH radical scavenging activity (In-vitro anti-oxidant activity of G. pedunculata) of methanolic extract shows 38.31 as IC50 (μg/ml) whereas Ascorbic acid as standard in the same concentration shows 34.81 IC50 (μg/ml). The obtained result justified the traditional use of G. pedunculata as anti-pyretic and antioxidant purpose. Top Keywords G. pedunculata, Anti-pyretic, Pyrexia rat, Anti-oxidant, DPPH. Top |