Development and evaluation of floating tablets of lamivudine Sahoo Chinmaya Keshari1,*, Mishra Amiyakanta1, Prusty Amaresh1, Rao S. Ram Mohan2, Bhaskar Jimidi3 1Department of Pharmaceutics, College of Pharmaceutical Sciences, (Affiliated toBiju Patnaik University of Technology), Puri, Orissa 2Department of Engineering, Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia 3Department of Pharmaceutics, KLR Pharmacy College, Paloncha, Bhadradri Kothagudem, Telangana *Corresponding Author E-mail: sahoo.chinmaya83@gmail.com
Online published on 25 August, 2021. Abstract The present study was undertaken to develop floating tablets of lamivudine. The tablets were prepared by direct compression method. The prepared tablets were evaluated for pre compression parameters, post compression parameters, in vitro drug release study and in vitro buoyancy study. Among the prepared formulations F4 batch show 90.98% drug release in 12 h. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, and Korsmeyer Peppas. The result of optimized formulation releases drug up to 12 h in a controlled manner and follows Higuchi kinetics. Short term stability study at 40±2°C/75±5% RH for three months on the best formulation was performed showing no significant changes in thickness, hardness, friability, drug content and in vitro drug release. Top Keywords Direct compression, In vitro drug release, Higuchi, Stability study. Top |