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Research Journal of Pharmacy and Technology
Year : 2021, Volume : 14, Issue : 5
First page : ( 2535) Last page : ( 2539)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2021.00446

Formulation and evaluation of quetiapine loaded pressure sensitive adhesive patch for transdermal drug delivery

Agrawal Milan B., Patel Mayur M.*

Department of Pharmaceutics, Institute of Pharmacy, Nirma University, SG Highway, Chharodi, Ahmedabad: 382 481, Gujarat, India

*Corresponding Author E-mail: drmayurmpatel@gmail.com

Online published on 25 August, 2021.

Abstract

The present research work was intended to develop and characterize the transdermal adhesive patch of quetiapine using different types of acrylate, polyisobutylene and silicon adhesives. Various permeation enhancers such as 1, 8 - cineole, D-limonene, Azone, IPM and Oleic acid were also evaluated to achieve desired permeation rate and hence to attain the improved bioavailability of quetiapine as compared to oral formulation. Formulations prepared were evaluated for physicochemical characterization, permeability enhancement potential by ex vivo, and stability studies. The results of the optimized formulation showed peel strength of 423 ± 4.13 cN/cm, flux of 54.92 ± 0.79 (μg/h/cm2) and % drug content of 98.16 ± 0.43% which was stable up to six months in accelerated condition. The results of the study revealed that the developed transdermal patch of quetiapine can be a promising alternative which provides effective management of schizophrenia in terms of improved patient compliance and reduced dosage frequency.

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Keywords

Quetiapine, Pressure sensitive adhesives, Ex-vivo permeation, Permeation enhancers.

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