Investigation of aspartame effects on some blood parameters after oral administration in balb-c mice Alkhalil Diana Ali1,*, Yasein Moofeed2,** 1Master Student in Analytical and Food Chemistry Department Faculty of Pharmacy, Tishreen University, Lattakia, Syria 2Prof. Dr. in Analytical and Food Chemistry Department Faculty of Pharmacy, Tishreen University, Lattakia, Syria *Corresponding Author E-mail: dianaalialkhalil@gmail.com
**moufidy@tishreen.edu.sy
Online published on 25 August, 2021. Abstract No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. It was first approved by the US Food and Drug Administration (FDA) in 1981. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. these metabolites have some health risks specially on PKU (Phenyl Ketone Urea) patients who can't metabolize the amino acid phenyl alanine. This study aims to investigate the health effects of aspartame on Balb-c mice. 16 Balb-c mice were given physiological solution by oral gavage(control) and the study groups were given the recommended ADI (Acceptable Daily Intake) for mice (ADI = 250mg/kg/body weight) of Aspartame diluted in water for 15days, 30days. Glucose blood level, lipid profile, marker enzymes (ALT.AST.ALP, yGT) and uric acid were determined at the end of the experiment. The results of this study show that oral administration of aspartame (250mg/kg body weight) was correlated to a significant increase in the lipid profile, fasting blood glucose and some marker enzymes and this increase is time related. Top Keywords Aspartame, Mice, Oral, ADI, Glucose, Lipid profile, Enzymes. Top |