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Research Journal of Pharmacy and Technology
Year : 2008, Volume : 1, Issue : 1
First page : ( 22) Last page : ( 24)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Synthesis and Analgesic Activity of Some Mannich Bases of 6-Substituted-2-Aminobenzothiazole

Bele D. S.1, Singhvi I.2,*

1B N Girls’ College of Pharmacy, Udaipur (Raj.) 313 001

2Pacific College of Pharmacy, Pratap Nagar, Airport Road, Udaipur (Raj) 313 003

*Corresponding Author E-mail: indrajeetsinghvi@yahoo.com

Abstract

Mannich reaction between 6-substituted-2-aminobenzothiazole and 1-(5-substituted-1H-1,2,4-triazol-1-yl) ethanone in presence of formalin yield ten new mannich bases. All the synthesized compounds were characterized by UV, IR and 1H-NMR spectroscopy. The analgesic activity of the synthesized compounds was evaluated, on albino mice, by hot plate method using acetyl salicylic acid as reference standard. The present investigation results into compounds possessing good analgesic activity.

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Keywords

Mannich reaction, 2-aminobenzothiazole, Triazole, analgesic.

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