Hypoglycemic Effect of Foeniculum vulgare Mill. Fruit on Dexamethasone Induced Insulin Resistance Rats Dongare VR1,*, Arvindekar AU2, Magadum CS3 1Appasaheb Birnale College of Pharmacy, Sangli 2Department of Biochemistry, Shivaji University, Kolhapur 3Ashokrao Mane College of Pharmacy, Pethvadgaon. (M.S) India *Corresponding Author: V R Dongare, Appasaheb Birnale College of Pharmacy, Sangli E-mail: gavadepj@gmail.com Phone No.9158563004, 0233 2320062
Online published on 21 March, 2013. Abstract Aim To assess the hypoglycemic effect of Foeniculum vulgare Mill. Fruit on dexamethasone induced insulin resistance rats. Method Wistar male rats (n=5) were made insulin resistance by administering dexamethasone injection subcutaneously to the overnight fasted rats and continue till the end of the experiment along with methanolic extract of Foeniculum vulgare Mill. Fruit for test and pioglitazone for std. At the end of the experimental period i.e. on day 11th the animals anesthetize with ether, blood was collected by retroobital puncture and serum separated for the estimation of glucose, triglycerides, cholesterol, insulin. The animals were weighed at the beginning and at the end of experimental period. The liver and muscle glycogen was also measured. Results Methanolic extract of Foeniculum vulgare Mill. Fruit lowers blood glucose, triglycerides, cholesterol and increase liver and muscle glycogen in dexamethasone induced insulin resistance rats. Conclusion The present study was indicating that Foeniculum vulgare Mill. Fruit showed significant glucose and triglyceride lowering activities as compared with diabetic control. In comparison with standard pioglitazone, Foeniculum vulgare Mill. Fruit showed comparable serum glucose lowering and better triglyceride lowering activity. Top Keywords Insulin resistance, Foeniculum vulgare, Dexamethasone, Blood glucose. Top |