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Journal Of Veterinary Pharmacology And Toxicology
Year : 2019, Volume : 18, Issue : 1
First page : ( 48) Last page : ( 52)
Print ISSN : 0972-8872.

Effect of withania somnifera root extract against monocrotophos -induced altered responsiveness of chicken duodenum to acetylcholine

Gupta Shefali1,*, Singh S.P.2, Mehboob2

1Veterinary Officer, Govt Vety Hopital Diagnosis LaboratoryBabugarh, Hapur, U.P.

2Department of Pharmacology & Toxicology, College of Veterinary and Animal Sciences, G. B. Pant Univ of Ag & Technology, Pantnagar-263145

*Corresponding author e-mail: gshefu@gmail.com

Online published on 29 June, 2021.

Abstract

The contractile responses of isolated duodenal segments from chickens treated with monocrotophos (MCP) alone and in combination with Withania somnifera root extract (WRE) were studied using 4 channel polygraph (Biopac, USA). The study consisted of 5 groups with 12 birds in each group. Group I served as control. Monocrotophos (2 ppm in feed) was fed to chickens of group II to V and WRE (@ 100, 300 and 500mg/kg b. wt/day) was given in drinking water to birds of group III to V, respectively for 7 weeks. The cumulative doses of acetylcholine (0.01-300 μM) caused dosedependent contractions with significant increase in Emax and decrease in EC50 values in MCP-exposed group II birds. Dose-response curve of ACh in group II birds was shifted to left. WRE significantly decreased responses of ACh in duodenum of chickens of group III to V. These findings demonstrated that MCP increased the responsiveness of muscarinic receptors in chicken duodenum and WRE had protective efficacy against MCP-induced alterations in responsiveness of cholinergic receptors to ACh in the tissue preparations.

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Keywords

Monocrotophos, Acetylcholine, Intestinal tissues, Withania somnifera.

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