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Journal Of Medical Erudite
Year : 2013, Volume : 1, Issue : 2
First page : ( 17) Last page : ( 25)
Print ISSN : 2278-1927.

Epidermal Growth Factor Receptor Expression in Hormone Receptor Positive and Negative Primary Invasive Breast Cancer

Maurya Geeta*,1, Naval Ram**, Chaturvedi Arun***, Husain Nuzhat****, Babu Suresh*****

*Department of Pathology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi-110025, India

**Department of Pathology, S G P G I M S, Lucknow, Uttar Pradesh, India

***Department of Surgical Oncology, KG Medical University, Lucknow, Uttar Pradesh, India

****Department of Pathology, RMLIMS, Lucknow, Uttar Pradesh, India

*****Department of Pathology, KG Medical University, Lucknow, Uttar Pradesh, India

1Corresponding author E-mail: geetamaurya13@gmail.com

Online published on 27 March, 2014.

Abstract

Breast cancer is the leading cause of cancer deaths among women. For this reason there is continuous search related to its prognostic markers which are useful in breast management. Epidermal Growth Factor Receptor (EGFR) is concerned with cell growth control, cell adhesion, mobility and apoptosis of cells. Uncontrolled cell division results due to constant activation of EGFR after any mutation. This constant activation leads to cancer development. Therefore EGFR molecule is a prime target for cancer targeted therapy. There are very few studies which correlate EGFR expression with estrogen receptor/progesterone receptor (ER/PR) positive or negative primary invasive breast cancer. This study was aimed at evaluation of expression of EGFR in primary invasive breast cancer and its correlation with other prognostic factors also. Study was done on 25 primary invasive breast cancer in which 12(48%) cases were ER/PR positive and the remaining 13(52%) were ER/PR negative. We found that statistically there was no significant difference between the two groups (p=0.656). Though the intensity of expression was stronger among ER/PR negative group specimen (30.8%), yet the difference from ER/PR positive group was not significant statistically. No correlation could be established between EGFR and other prognostic factors of primary invasive breast cancer such as histological grade, TNM stage, type of tumour and axillary lymph node metastasis. We concluded that EGFR expression was independent of the ER/PR status and other prognostic factors.

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Keywords

Primary, Invasive carcinoma, Breast, ER/PR receptor, Epidermal Growth Factor Receptor.

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