Evaluation of the anti-inflammatory and anti-hemolytic potential of polyphenolic components of common mallow (Malva sylvestris) Belkhodja H.1,*, Bouhadi D.1, Sedjrari K.2, Sehanine S.2 1Laboratory of Bioconversion, Microbiology Engineering and Health Safety, University of Mustapha Stambouli, Mascara, 29000, Algeria 2Department of Biology, University of Mustapha Stambouli, Mascara, 29000, Algeria *Corresponding Author: H. Belkhodja, Laboratory of Bioconversion, Microbiology Engineering and Health Safety, University of Mustapha Stambouli, Mascara, 29000, Algeria, Email: hamzabelkhodja@yahoo.fr
Online published on 5 July, 2024. Abstract Background This work aims at the assessement of anti-inflammatory and anti-hemolytic effect of Malva sylvestris. Methods The anti-inflammatory potential was evaluated by the inhibition of protein denaturation method. It was followed by the study of anti-hemolytic potential, based on two methods (haemolysis by hydrogen peroxide (H2O2) and by hypotonic haemolysis). Result The macerated aqueous extract of M. sylvestris (250 μg/ml) exhibited the highest inhibition percentage of BSA denaturation compared to other extracts but it appeared to be slightly lower than the drug diclofenac sodium (80.97±1.23%). On the other hand, the macerated aqueous extract showed more protective power against haemolysis (93.42±3.45%). While it was almost similar to the percentage recorded for ascorbic acid (93.68±3.21%). For the second method, it was observed that the decocted acetone extract of M. sylvestris showed a rate of haemolysis inhibition which was the highest (98.09±1.26%) but that it remained slightly lower than aspirin (98.77±0.44%). All of these results showed that M. sylvestris extracts have interesting anti-inflammatory and anti-haemolytic potential and therefore have considerable interest as an alternative treatment against inflammatory mechanisms. Top Keywords Anti-hemolytic, Anti-inflammatory, Malva sylvestris, Polyphenols. Top |