Clinical, physiological and haematobiochemical effects of detomidine with or without atropine in diazepam premedicated dogs Parikh P.V., Ph.D. Scholar, Kumar Amresh, Professor and Head, Sharma B., Ph.D. Scholars, Tiwari S.K., Ph.D. Scholars, Jadon N.S., Assistant Professor, Surgery and Radiology G.B. Pant University of Agriculture & Technology Pantnagar, 263 145 (Nainital) Abstract Detomidine @ 50 μg/kg body wt. and 100 μg/kg body wt. I.M. with or without atropine @ 0.04 mg/kg body wt. I.M.in diazepam (2 mg/kg body wt. I.V.) premedicated dogs caused deep sedation/analgesia lasting for 79.5 and 120.5 minutes, respectively. A dose dependent increase in duration and recovery was seen after detomidine administration. The administration of detomidine caused non- significant decrease(p>0.05) in heart and respiratory rates. TEC, PCV, Hb and TLC decreased 30 minutes after detomidine administration in all the animals. A significant (p<0.05) increase in glucose level and nonsignificant (p>0.05) decrease in total protein, albumin and increase (p >0.05) in ALT, AST, BUN and creatinine was observed at 1 hour after detomidine administration. Haematological and biochemical parameters returned to near preadministration level by 24 hours of initial injection. All animals, irrespective of dose, showed depression of pedal and cough reflexes during maximum depth of sedation where as palpebral and corneal reflexes were not abolished. Top Keywords Atropine, Detomidine, Diazepam, Dog. Top |