Effect of induced chronic glyphosate toxicity in liver and kidneys of kuroiler birds Kalai K.4,*, Upadhyaya T.N.4, Pathak D.C.4, Roy D.C.1,4, Sarma Satya2,4, Saikia G.K.3,4 4Department of Veterinary Pathology, College of Veterinary Science, AAU, Khanapara-781022, and SAIF, NEHU, Meghalaya, India 1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, AAU, Khanapara-781022, and SAIF, NEHU, Meghalaya, India 2Department of Veterinary Biochemistry, College of Veterinary Science, AAU, Khanapara-781022, and SAIF, NEHU, Meghalaya, India 3Department of Veterinary Microbiology, College of Veterinary Science, AAU, Khanapara-781022, and SAIF, NEHU, Meghalaya, India *Address for Correspondence Dr. Kanika Kalai, Assistant Professor, Department of Veterinary Pathology, College of Veterinary Sciences and A.H, R.K. Nagar, Tripura-799008, India, e-mail: kanikakalai@gmail.com
Abstract The present study was conducted in 3 month old kuroiler birds divided into 2 groups with 25 birds in each group. Group I comprised of control birds and group II had chronic experimental birds consisting of Group II birds were given glyphosate formulation @ 27.8 mg/kg body weight orally for 90 days. Group I birds were given plain water. Blood was collected on 0 day, 7th day, 14th day and every fortnight afterwards till 90 days. Blood samples were analyzed for haematological and biochemical parameters. The birds were sacrificed at weekly interval after 60 day post glyphosate feeding till the end of the experiment. Liver and kidney tissue samples were collected for histopathological and ultrastructural analysis. Haematological study revealed decreased mean Hb, TEC, PCV in group II in comparison to group I birds. Increased serum GGT, LDH, creatinine levels were observed in glypho- sate treated birds. Histopathological changes in liver showed mild to moderate congestion, haemorrhage, focal mononuclear cell aggregation, hepatocellular necrosis, dilation of sinusoids, fatty changes and disruption of hepatic cords. Congestion and focal to diffuse haemorrhage in renal parenchyma, hydropic degeneration in renal tubule and dilation of Bowman's space in glomerulous were observed in histopathological examination of Kidneys. Various ultrastructural changes were observed in mitochondria, nuclear membrane and endoplasmic reticulum of hepatocytes and renal tubular cell. It can be concluded that chronic oral exposure to glyphosate is hepatotoxic and nephrotoxic in kuroiler birds. How to cite this article: Kalai, K., Upadhyaya, T.N., Pathak, D.C., Roy, D.C., Sarma, S., Saikia, G.K. Effect of induced chronic glyphosate toxicity in liver and kidneys of kuroiler birds. (2019). Indian J. Vet. Pathol., 43(3):211–216. Top Keywords Glyphosate, Kuroiler, Pathology, Toxicity, Ultra-structure. Top |