Pathology of fenvalerate toxicity in broiler chicks and its amelioration with vitamin E Murty R.V. Ramana1, Sujatha K.1,*, Srilatha Ch.1, Sreenivasulu D.1 1Department of Veterinary Pathology, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati-517502, Andhra Pradesh, India *Corresponding author: e-mail: karamalasujatha@gmail.com
Abstract The present study was conducted to evaluate the histopathological alterations in experimentally induced fenvalerate toxicity and ameliorating effect of vitamin E in broiler chicks. For this study, one hundred fifty apparently healthy unsexed broiler chicks (White Leghorn) were randomly divided into five groups. The control chicks were fed with normal feed without fenvalerate. Group I and II were fed with 20 ppm/kg feed and 40 ppm/kg feed Fenvalerate respectively. Group III and IV chicks were fed with 20 ppm/kg feed and 40 ppm/kg feed Fenvalerate respectively along with Vitamin E @ 2.5 ml each (62.5 mg) in water. Grossly kidney showed enlargement, moderate to severe congestion with mild haemorrhages. Liver revealed paleness, congestion with areas of blotchy haemorrhages. Hydropericardium is noticed in heart. Thymus and spleen showed mild atrophy with petechial haemorrhages. Microscopically, kidney revealed mild fatty change, intertubular fibrous tissue proliferation and focal atrophy of renal tubules.Tubular necrosis in kidneys was evident in group II and IV. Periportal fibrosis, hyperplasia of bile ductular epithelium and individualization of hepatocytes were noticed in liver. Mild haemorrhages and mild to moderate depletion of lymphocytes were noticed in thymus, bursa and spleen. The ameliorative effect of vitamin E @ 2.5ml (62.5mg.vitamin E) was negligible. Toxic changes were noticed mainly in kidney followed by liver indicating the nephrohepato toxic nature of the fenvalerate. The changes in bursa and thymus are indicating the immunosuppressive effect. Top Keywords Broiler chicks, Fenvalerate toxicity, Histopathology, Vitamin E. Top |