Toxicopathological studies of Carprofen in broiler chicks Dabhi P.B.1, Ghodasara D.J.1,*, Pandey Sunanda1, Ghodasara Priya D.1, Patil V.M.1, Kapadiya Komal1, Joshi B.P.1 1Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat, India *Corresponding author: e-mail: dinghodasara@gmail.com
Abstract A toxico-pathological study was undertaken to assess the effects of Carprofen administration in broiler chicks by performing the serum biochemical analysis and-associated histopathological changes in visceral organs.One hundred day old cobb broiler chicks were randomly divided in to 4 treatment groups with 20 chicks each and were administered carprofen (Group II to IV) at the dose rate of 25, 50 and 100 ppm through feed for 21 consecutive days along with distilled water as vehicle control in Group I. Clinical signs, mortality, feed intake, weight gain, FCR, serum biochemical parameters and patho-morphological studies were done.The abnormal behavioral clinical signs like dullness, lethargy, lameness, anorexia, feather plucking and uneven growth were noticed in chicks of treatment group IV with varied severity. Maximum mortality was observed in group IV (12%) followed by group III (4%). A dose dependent reduction in body weight and feed consumption was observed in all the treatment groups. There was a dose dependent significant increase in the mean values of Kidney: Body weight ratio in group III and IV. Highest FCR of 1.38 was observed in group IV followed by 1.34 in group III. The serum uric acid, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (AKP) values were significantly increased in treatment group IV. Grossly, white chalky urate deposits of varying degree on surface of visceral organs were observed in chicks which died during experiment from treatment group IV. Histopathologically, the lesions were characterized by congestion, degeneration, necrosis, haemorrhage and deposition of uric acid crystals. Kidney was the main target organ affected. It can be concluded from this study that carprofen was nephrotoxic as well as hepatotoxic in nature which causes visceral gout in broiler chicks. Top Keywords Broiler, Carprofen, Toxicopathology. Top |