Toxicopathological studies of aceclofenac in broiler chicks Patil V.M.4, Patel N.J.1,4,*, Jivani B.M.2,4, Dave C.J.3,4, Joshi B.P.3,4 4Government Veterinary Officer of Maharashtra, 1Government Veterinary Officer of Gujarat 2Private practitioner at Mumbai 3Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand-388001, Gujarat, India *Corresponding author: e-mail: nikitajpatel88@yahoo.in
Abstract The experiment was conducted to evaluate the toxicopathology of aceclofenac in Cobb 400 broiler chicks. Hundred Cobb 400 day old broiler chicks were randomly divided into four equal groups and treated with aceclofenac at the dose rate of 0, 10, 20 and 30 ppm orally through feed for 21 consecutive days. The affected birds exhibited the signs of toxicity as emaciation, anorexia, depression, lethargy and lameness with shrunken eyes. Mortality rates in 10, 20 and 30 ppm groups were 8, 28 and 48%, respectively. Mortality in male and female broilers was 57.14 % and 42.86 % respectively. Marginal reduction in feed consumption and body weight but increase in FCR and kidney: body weight ratio was observed. Gross lesions included visceral gout characterized by focal to multifocal extensive urate precipitates on almost all the visceral organs. Microscopic lesions showed urate crystals deposition in amorphous or radiating form. A strong correlation in the toxicity of the drug and elevation of the serum uric acid, creatinine, BUN, AST, ALT and ALP concentrations was observed in the treatment birds. The present study indicates that aceclofenac is hepatotoxic as well as nephrotoxic which causes visceral gout in Cobb 400 broiler chick. Top Keywords Aceclofenac, Broiler chicks, Hepatotoxic, Nephrotoxic, Toxicity, Visceral gout. Top |