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Year : 2012, Volume : 36, Issue : 2
First page : ( 247) Last page : ( 248)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2012 December 1.

Pathology of epidermoid cyst in the spinal cord of swiss albino mice

Prasad M.C.1,*, Brahmankar M.G.1, Kapurkar U.M.1, Adak A.1, Lonkar P.S.1, Patel M.V.1, Pavitrakar Vishal1, Bokan Sanjay1, Sharma Sharad1

1Pathology Section Department of Toxicology, Jai Research Foundation, Vapi-396195, Gujarat, India

*Corresponding author: email: pathology@jrfonline.com

Received:  17  July,  2012; Accepted:  14  November,  2012.

Abstract

Two cases of epidermoid cyst were recorded one each in male and female Swiss albino mice (3–4 months) out of about 2000 mice used in various toxicity studies. These were located in the white matter of lumber segment of spinal cord. No clinical sign during life phase and gross lesion on necropsy were recorded. Histopathological features consisted of multilayered stratified squamous epithelial cystic wall having either keratinaceous debris or concentric laminated layers of keratin in the lumen. It was considered to be an incidental finding of congenital origin.

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Keywords

Epidermoid cyst, Histopathology, Mice, Spinal cord.

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ACKNOWLEDGEMENTS

Authors are thankful to the Management of Jai Research Foundation, Vapi and Lupin, pharmaceuticals, Pune for extending the facilities and grant of permission to publish the findings.

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Figures

Fig. 1.:

Irregularly oval epidermoid cyst embedded in white matter and lined by stratified squamous epithelium containing desquamated keratin in lumen. H&E ×100;




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Fig. 2.:

Irregularly oval epidermoid cyst embedded in white matter and lined by stratified squamous epithelium containing concentric layers of desquamated keratin in lumen. H&E ×100.



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