Effect of trivalent chromium on haemato-biochemical and histopathological parameters at higher doses in broilers Raut S.S.1, Ganorkar A.G.1,1, Bhandarkar A.G.1,*, Jangir Babu Lal1, Mahaprabhu R.1, Kurkure N.V.1 1Department of Pathology, Nagpur Veterinary College, Maharashtra Animal and Fishery Sciences University, Seminary Hills, Nagpur-440006 *Corresponding author:
Abstract An experiment was conducted in equally distributed 7 groups of 140, day old broilers to study the effect of trivalent organic chromium picolinate (Cr-Pic) @ 40, 80, 120mg/kg and inorganic chromium chloride (CrCl3) @ 80, 120, 200mg/kg feed in group B,C,D,E,F and G, respectively. Group A was kept as control. The hematological and biochemical parameters were studied at weekly interval, whereas, patho- morphological studies was conducted on day 21 and 42. Experimental birds did not exhibit any clinical signs of toxicity during the period of observation. The groups B and D receiving Cr-Pic showed higher body weights while the lowest body weights was recorded in the groups F and G receiving CrCl3 @ 120mg and 200mg/kg respectively. Haematological observations revealed anaemia in all the treatment groups receiving CrCl3 on the other hand groups received Cr-Pic showed increased TEC, Hb and PCV values. Mild heterophillia with relative lymphopenia was observed. The serum glucose and cholesterol was decreased significantly in all the groups receiving organic and inorganic chromium with increased levels of serum creatinine and AST levels. Histo-pathologically, liver showed granular degenerative changes, periportal and perivascular necrosis with bile duct hyperplasia in birds receiving higher doses of chromium. Various degenerative changes in tubular epithelium and accumulation of hyaline cast in kidney tubules were noticed. Hyalinization of glomeruli and interstitial nephritis along with fibrous tissue proliferation were evident in group receiving higher dose of CrCl3. Present investigation suggest that organic and inorganic trivalent chromium salt produces histo-pathological alterations in liver and kidney. Top Keywords Chromium, Broiler, Haematobiochemical, Histopathological. Top |