Clinico-biochemical and histopathological findings in microfilariosis associated nephropathy in dogs Ambily V.R.2, Pillai Usha. N.2,*, Pramod S.1,2, Kanaran P.P.2, Jayakumar K.M.2 2Department of Clinical Veterinary Medicine, Centre of Excellance in Pathology College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala 1Centre of Excellance in Pathology College of Veterinary and Animal Sciences, Mannuthy, Thrissur, Kerala. *Corresponding author: e-mail: ushanpillai@yahoo.com
Abstract The present study was carried out to elucidate the possible role of microfilariae in renal diseases in dogs. Hundread dogs above six months of age with clinical signs suggestive of microfilariosis and positive for microfilaria by wet film examination were subjected to detailed study and treatment trials. Two animals died during the course of treatment were subjected to postmortem examination and histopathological evaluation. Results of ultrasonographic evaluation, biochemical and urinalysis and histopathological evaluation were highly correlated to suggest an impending renal insult. Nephrotoxic changes could be reversed if treatment instituted at an early stage. This renal pathology in canine microfilariosis suggested the involvement of toxic and immunological effects of filarial parasites in the pathogenesis of the disease. Top Keywords Dirofilaria, Microfilaria, Nephritis, Renal failure, Ultrasonography. Top |