Haemato-biochemical and immunological studies in arsenic fed guinea pigs Kumar Dinesh1, Srivastava A.K.*,1, Kumar Sanjiv1 1Department of Veterinary Pathology, Veterinary University, Mathura-281 001, U.P. *Corresponding author; e-mail: aksvetpath@rediffmail.com
Abstract In the present study, guinea pigs were given 1% aqueous solution of arsenic trioxide once @ 10 mg/kg body weight through single oral gavage to produce acute toxicity and @ 1 mg/kg body weight through oral gavages daily for 90 days to produce chronic toxicity. All the arsenic fed guinea pigs showed varying degree of clinical symptoms. The mean values of haemoglobin, PCV, TEC and TLC were decreased. There was decrease in protein values, while increased in values of glucose, urea, cholesterol, creatinine, bilirubin, AST, AST and ALP. Response to DNCB showed decrease in the skin thickness indicating poor reactivity of host against the mitogen by the cell mediated immune response. Top Keywords Arsenic trioxide, Cell mediated immune response, Guinea pigs, Haematology, Hyperuremia, Serum chemistry. Top |