Pathological changes induced by Jatropha seeds in Wistar rats Awasthy Vijeyta2,*, Vadlamudi V.P.2, Koley K.M.2, Awasthy B.K.2, Ghosh R.C.1,2 2Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anjora, Durg (Chhattisgarh) 1department of Pathology, College of Veterinary Science and Animal Husbandry, Anjora, Durg (Chhattisgarh) *Corresponding author; e-mail: vijeytavet@gmail.com
Abstract Short-term toxicity study was conducted in rats by daily feeding the basal diet (Group I), and the diet where the crude protein requirement was supplemented at 25 % (Group II) and 50 % (Group III) levels through locally grown Jatropha curcas seed powder. The adverse effects of Jatropha seed protein supplementation (JSPS) were evaluated by observing alterations in pathological changes. Gross necropsy of rats that succumbed to the toxicity of JSPS showed congested visceral organs in general, where the intestines were grossly engorged with haemorrhages. Histopathological changes observed were characterized by degenerative changes and necrotic lesions in liver parenchyma and in the proximal and distal convoluted tubules in kidneys, congestion and desquamation of superficial epithelium in intestines (duodenum and jejunum), and degenerative changes in seminiferous tubules along with few spermatids with elongated nuclei. Top Keywords Jatropha curcas, Pathology, Rats, Seed, Toxicity. Top |