In vitro anti-helminthic activity of hydro-alcoholic extract of murraya exotica linn leaves against pheretima postuma Aishwarya M. N. L.1, Shankar M.1,,*, Mounika J., Ashifa S.2, Sireesha N.2, Mounika P.2, Babu M. Niranjan2 1Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya (D)-571448, Karnataka, India 2Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati-517561, Andhra Pradesh, India *Corresponding Author M. Shankar, Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya, Email: shankarmanichellappa@gmail.com
Online published on 1 May, 2020. Abstract Anthelmintic resistance creates a major hitch over the decades throughout the world. Helminthes infections, repeatedly entitled helminthiasis are among the most pervasive infection and a foremost degenerative disease distressing a large proportion of world's population. In developing countries, they pose a large threat to public health. As per WHO only few drugs are frequently used in the treatment of helminth infestations in human beings. The aim of the present study was to determine the anthelmintic activity of hydro-alcoholic extract of Murraya exotica (HAME) on Indian earth-worm (Pheretima posthuma). Three concentrations (12.5 mg/ml, 25mg/ml & 50 mg/ml) of HAME were tested and results were expressed in terms of time for paralysis and death of worms. Albendazole (10 mg/ml) was used as reference standard and CMC (1% w/v in normal saline) as a vehicle control. Dose dependent activity was observed with HAME as compared to standard drug. Top Keywords Murraya exotica Linn, Anthelmintic activity, Pheretima posthuma, Albendazole, Hydroalcohol. Top |