Biochemically and histopathologically evaluation of intravenous lipid emulsion adverse effect on tramadol toxicity in adult male albino rats Ghaleb Sherien S.1, Alroby Fadwa A.2, Sayed Marawa M.3, Elazeem Naglaa A. Abd4, Sobhi Ahmed G.5,,* 1Professor of Forensic Medicine and Clinical Toxicology Department, Cairo University 2Lecturer of Forensic Medicine and Clinical Toxicology Department, Beni-Suef University 3Lecturer of Pathology Department, Beni-Suef University 4Lecturer of Biochemistry Department, Beni-Suef University 5Assistant Lecturer of Forensic Medicine and Clinical Toxicology Department, Beni-Suef University *Corresponding Author, Ahmed Gamal Sobhi, Tel: +2 01110697968, E-mail address: ahmadjamal_5@hotmail.com
Online published on 1 May, 2020. Abstract Background Tramadol is a synthetic analgesic drug acting centrallyto treat moderate to severe degree of acute or chronic pain. Tramadol overdose lead to hepatic and renal toxicity. Intravenous lipid emulsion (ILE) considered as vulnerable treatment for local anesthetic intoxication, and treating overdoses of parasiticides and herbicides. The aim of our work was to evaluate the role of ILE in treatment of acute tramadol toxicity as regarding different biochemical and pathological parameters of liver and kidney in adult male albino rats. Methods Randomly 120 mature male albino rats divided into four groups: Group I serve as control. Group II: ILE group (subdivided into ILE10, ILE19 subgroups). Group III (tramadol group). Group VI: divided into tramadol+ILE10 and tramadol+ILE19 subgroups. From all animals, tissue and bloodsamples taken at 24 hours at death time for chemical and pathological studies. Results ILE could significantly decrease in serum ALT, AST, Creatinine and Urea, which elevated with using the overdose of tramadol (200 mg/kg). In addition, elevation in serum Glucose level and causing significant improvement of pathology of liver and kidney. Serum CPK were significantly raised after tramadol toxicity but reduced to normal ranges when used ILE10. ILE19 caused more elevation in CPK levels and mortality occurs. Conclusions ILE could significantly improve biochemical and histopathological affection of hepatic & renal evoked by tramadol toxicity. Recommendation: to do further in vivo studies needed to evaluate role of ILE in chronic tramadol using. The potential risks of administering the quite high doses of ILE are uncertain and needs more researches. Top Keywords Tramadol toxicity, Intravenous lipid emulsion. Top |