Effect of resistance exercise training associated with skeletal muscle hypertrophy on serum pro-inflammatory cytokines in STZ-induced diabetes Shamsi Mahdieh Molanouri1,*, Fallah Mohsen2, Ghaderi Mohammad3 1Department of Physical Education & Sport Sciences, Taft Branch, Islamic Azad University, Taft, Iran 2Department of Physical Education & Sport Sciences, Taft Branch, Islamic Azad University, Taft, Iran 3Department of Physical Education & Sport Sciences, Mahabad Branch, Islamic Azad University, Mahabad, Iran *Corresponding Email: Mahdieh_molanouri@yahoo.com
Online published on 29 September, 2018. Abstract Skeletal muscle atrophy is associated with type 1 diabetes. Effects of resistance exercise training associated with skeletal muscle hypertrophy on serum inflammatory cytokines was exactly not clarified. Protein levels of inflammatory cytokines IL-6, TNF-α, and interleukin-1beta (IL-1β) in serum of healthy and streptozotocin (STZ)induced diabetic rats subjected to resistance exercise training were assessed in this study. Rats were divided into the control, training, control diabetic and diabetic training groups. Training groups performed the resistance training consisted of climbing a 1 m ladder with increasing weight added to the tail. Proteins levels of IL-6, TNF-α and IL-1β in serum were measured by the ELIZA method. The results of this study indicated that resistance training induced skeletal muscle hypertrophy in diabetic samples (P<0.05). Also, Resistance training decrease IL-6 protein levels in serum. Inflammatory cytokines could act as stress factors in diabetes. It seems that this kind of exercise training individually could not change cytokines levels in serum. Top Keywords Inflammatory cytokines, Resistance training, Type-1diabetes. Top |