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International Journal of Medical Research & Health Sciences
Year : 2012, Volume : 1, Issue : 1
First page : ( 13) Last page : ( 20)
Online ISSN : 2319-5886.

Comparative effect of fixed dose combination of Amlodipine + Bisoprolol versus Amlodipine and Bisoprolol alone on blood pressure in stage-2 essential hypertensive patients

Shirure PA1,*, Tadvi NA2, Bajait CS3, Baig MS4, Gade PR5

1Dept of Pharmacology, GMC, Nanded, Maharashtra

2Dept. of Pharmacology, KIMS, Narketpally, Andhra Pradesh

3Dept of Pharmacology, GMC, Nagpur, Maharashtra

4Dept of Pharmacology, GMC, Aurangabad, Maharashtra

5Dept of Pharmacology, MIMSR Medical College, Latur, Maharashtra

*Corresponding author Email: drprashantshirure@yahoo.com

Online published on 6 April, 2013.



Employment of low dose combinations of two antihypertensives, with different mode of action has gained acceptance worldwide for the treatment of mild to moderate hypertension. However, most studies in hypertensive disease have focused on monotherapy. The combination therapy in the treatment of hypertension is largely extrapolated from these monotherapy studies.


To study and compare the effect of amlodipine, bisoprolol and fixed dose combination of amlodipine + bisoprolol on blood pressure in stage-2 essential hypertensive patients.


The present study was carried out in Department of Pharmacology in collaboration with Department of Medicine at Government Medical College and Hospital, Aurangabad.

Results and Conclusion

Amlodipine + bisoprolol in fixed dose combination have showed significant blood pressure control in patients of stage-2 essential hypertension and the antihypertensive effect was greater than individual monotherapy study groups.



Amlodipine, Bisoprolol, Hypertension stage-2.


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