Case Control Study: Estimation of Vitamin D Deficiency in Relation to Urinary Stones Formation among Tikritmale Population NejresHilal Nihad1, MohammedMohsin2, Ibraheem Nisreen M.3, Suleiman Shihab A.4, Assim Hiba S.4, Ahmed Farah Y.4 1Chemical Pathology, Tikrit Medical College 2Urosurgery, Tikrit Medical College 3Community and Family Medicine, Tikrit Medical College 4Researcher, Tikrit Medical College Online published on 27 November, 2019. Abstract Background Renal stones is a common, highly recurrent disease with increasing prevalence worldwide. The association between vitamin D and calcium stones has often been investigated on the basis of the role of vitamin D in calcium homeostasis. Currently, there is no consensus on the management of vitamin D deficiency in patients with renal calculi, because of controversies about the relationship between vitamin D and calcium stones. However, the vitamin D deficiency is shown to be highly prevalent among kidney stone formers, and some studies found a higher prevalence in stone formers compared with non-stone formers. Mechanism for the association between vitamin D deficiency and calcium-based calculi according to the substantial role of inflammation and oxidative stress in calcium stone formation and also the pro-inflammatory effect of vitamin D deficiency. Aim Evaluation the relation between vitamin D deficiency and renal stones formation. Patients and methods This study is case control study performed from the 1st of November 2018 to 3rd of April 2019. The study included 100 male persons (50 cases of renal stone, and 50 persons control group(free renal stones but shared most other sociodemographic characteristics), sample was selected by convenience sampling method. Serum levels of vitamin D were done for both groups by boditech kit. The test uses competitive immunodetection method. Results Results regarding the relation between level of vitamin D and renal stone formation show decrease serum level of vitamin D associated with renal stone (32%) in compare with the serum level of vitamin D in control group (12%), odd ratio (3.5). Conclusions The study showed that the frequency of vitamin D deficiency increasing in patients with renal stones. Renal stones formation was more frequent among positive family history cases. Top Keywords Vitamin D, Renal stone, Tikrit population. Top |