Gut dysbiosis and its potential impact on immunomodulation Ghatak Anamika, Ghosh Shonima Talapatra* Department of Microbiology, Tara Devi Harakh Chand Kankaria Jain College, Ram Gopal Ghosh Road, Cossipore, Kolkata, India *Corresponding author: shonima_talapatra@yahoo.com
Online published on 26 March, 2025. Abstract Past decades have witnessed an increasing trend of various types of metabolic disorders in young adults all over the world. Majority of these ailments have been found to be connected with unhealthy dietary habits which seriously disturbs the consortia of microbes that inhabit in our gut. The microorganisms naturally present in human digestive tract are referred to as the gut microbiota and collective form of their genome constitute the gut microbiome. These microorganisms play crucial role in maintaining normal nutrition, metabolism and immune function in our body; hence, has attracted substantial attention of researchers. The gut microbiome always remains in symbiotic association with the host. Any kind of imbalance in the composition of the gut microbiome leads to dysbiosis causing various types of gastrointestinal disorders like inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), diabetes, obesity, atopy and even mental illness. It is therefore, of utmost importance to take care of the gut microbiota for getting a healthy mind and a healthy life as well. This review is intended to investigate and establish the risk of immune dysfunction affected by gut dysbiosis. Top Keywords Gut microbiome, Dysbiosis, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Immunomodulation, Short Chain Fatty acids (SCFAs). Top |