Insilico Studies of Ras Protein in Cancer reddy A. Ranganadha1,*, Krupanidhi S.1, Sudhakar P.2 1Depertment of Biotechnology, VFSTR(Deemed to be University), Guntur, 522 213 2Department of Biotechnology, Acharya Nagarjuna University, Guntur, 522 510 *Corresponding author: rangaaluri@gmail.com
Online published on 30 December, 2019. Abstract Cancer can be defined as a set of cells that show uncontrollable growth, invasion and also metastasis takes place. Intracellular signaling pathways that have various functions in biological processes are regulated by Ras GTPase proteins and their down-stream effectors. These proteins causes spreading within the cell cycle and also the balance of pro-and anti-apoptotic factors are also affected. Ras controls different functions and also abnormalities and various points in the downstream signaling processes causes carcinogenesis and also the signal mechanisms can be used as therapeutic agents in treating cancer. They play a vital part in the cell development, maintenance and also transformations that are malignant. Changes in the signaling in both upstream and downstream can be caused by activating RAS. RASGRF2 gene is said to encode protein called Ras-specific guanine nucleotide-releasing factor 2. RAS GTPases can be seen in between active GTPbound state and inactive GDP-bound state. The GDP bound form transforms into active form and this is stimulated by GEFs (Guanine-nucleotide exchange factors) like RASGRFs. RAS protein structure was modeled by using SWISS MODEL and the model was validated by using PROCHECK. Top Keywords Cancer, RAS protein, SWISS MODEL, PROCHECK. Top |