A review on the lutheran blood group Bhosale M. S., Harkal A. D.1 Department of Forensic Biology, Institute of Forensic Science, Mumbai, (M.S.) 1Department of Zoology, New Arts, Commerce and Science College, Ahmednagar, (M.S) Online published on 23 October, 2023. Abstract The Lutheran blood group system consists of 20 glycoprotein antigens defined by clinically benign antibodies. The gene for the Lutheran antigens called BCAM or LU, is present on chromosome 19. The Lutheran antigens belong to a large immunoglobulin family that binds with the laminin, an abundant extracellular matrix of the vascular endothelium. The nature of the cytoplasmic and extracellular domains of the Lutheran glycoprotein suggest receptor and signal transduction functions such as the transfer of maturing RBCs from bone marrow to the peripheral circulation, adherence of RBCs to vascular endothelium and vascular occlusion and thrombotic events characteristic of sickle cell anemia and polycythemia vera respectively. Top Keywords Lutheran blood group, Laminin, Sickle cell anemia, BCAM, Polycythemia vera. Top |