Antigenotoxic Potential of Actinidia chinesis: Studies in the In Vitro and In Vivo Experimental Model Md. Ahmad Sultan*, Mrs. Sheeba, Gautam B.R., Ali Afsar Department of Zoology, Shibli National College, Azamgarh, Uttar Pradesh- 276001. *Email: sultansnz@yahoo.com
Online published on 16 February, 2013. Abstract The present study was carried out to evaluate the protective effects of Actinidia chinesis (Kiwi) extract against Aflatoxin B1-induced genotoxicity. Significant reduction of number of aberrant cells and frequency of aberration per cell in the bone marrow (bw) of albino mice in vivo, and the reduction of chromosomal aberrations (CAs), sister chromatid exchanges (SCEs), and enhanced replication indices in human lymphocyte cultures were observed. We also notice the positive dose-response relationship between the doses of Kiwi Extract and antigenotoxicity, using four optimum doses (150, 200, 250, 300, and 350 mg/kg bw.) of Kiwi Extract in vivo and four concentrations viz; 25, 50, 60, 80 and 90 μg/ml in in vitro study. The data were collected at three durations (16, 24, & 32 hrs in vivo and 24, 48, & 72 hrs in vitro); although the effect was not time dependent but it was dose dependent. Top Keywords Actinidia chinesis, Kiwi, antigenotoxicity, chromosomal aberration, sister chromatid exchange, replication index. Top |